Research Interest

The laboratories at CBM are technology platforms equipped with excellent scientific instrumentation, available for shared use by CBM researchers, partners of the Centre, and external users.

The multisciplinary approch is able to guarantee the development of advanced projects. Moreover the collaboration among various institutions working in different research areas promote the establishment of challenging environment.

Bioinformatics Research

> Bioinformatics
the application of IT and statistics to biological data analysis
> Cluster
group of computers connected to a data network for complex processing

> Applications
biomedicine, pharmaceutical, agricultural and food industries, artificial intelligence
> Bioinformatics and health
genomics, proteomics, pharmaco-genomics

> Why?
as a consequence of modern biology's need to store the enormous quantities of research data produced, it has become necessary to create, manage and maintain specialised data banks for automatic information retrieval. The uses are vast and varied, among them the possibility to retrace the evolution of the species, to study genetic mutations causing disease and to design novel targeted molecules and drugs

Proteomics

The Proteomics and Pharmacogenomics facility is located within the Centro di Riferimento Oncologico of Aviano (PN).
It is able to offer extensive and thorough service to carry out drug development and analysis, offering comprehensive and analytical chemical investigations in support of clinical chemotherapeutic drug development studies or standard drug regimens.

Optical Imaging Research

> Optical Imaging
molecular imaging procedure employed in pre-clinical examinations
> Molecular Imaging
non-invasive diagnostic technolgy allowing to visualize molecular processes

> Applications
healthcare
> Optical Imaging and health
neurobiology, tumor biology, angiogenesis, osteogenesis, regenerative medicine, pharmacology, ...

> Why?
thanks to genetic manipulation progresses and rapid evolution of animal models, researchers incresingly resort to preclinical imaging to visualize phenotypes, to examine disease progress and evaluate potential treatment.
Non-invasisve mapping of cellular and molecular events in vivo drastically enhances the quality and quantity of
information available to research, accellerating drug discovery and development and the path towards ever improving precocious diagnosis

Stem Cells

The laboratory is dedicated to the study on the mechanisms of regulation and proliferation/differentiation of stem cells and on their therapeutic applications in the field of tissue engineering and regenerative medicine

Genomics

> Genomics
a branch of science studying genome structure, function and content
> Gene
basic unit of heredity carried inside the DNA of living organsims

> Applications
research, clinical science, industry
> Genomics and health
examination of pharmaco-genomics, of hereditary diseases (anemia, cystic fibrosis, down syndrome, color blindness,...), of multifactor diseases (caused by the interaction of individual and environmental factors), of infectious diseases, etc...

>Why?
genomics progress is bringing about a radical transformation in the way medical prevention, diagnosis and treament of main maladies are addressed thanks to the design of genetic diagnostic tests, prediction tests and novel drugs, resulting in true personalized medicine.

Bio-Nanotechnology

> Nanotechnology
manipulation of matter at the nanometric level
> 1 nanometer (10-9)
one billionth of a meter

> Applications
research on matter, electronics, pharmaceutics, environment, aerospace, healthcare ..
> Nanotechnology and health
diagnostic (DNA nanoarray), therapeutic and regenerative medicine such as time -dependent release of drugs, in vivo imaging, tissue engineering, gene therapy,..

> Why?
at the nanometric level the properties of matter change: the more an object decreases in size the more its volume/surface ratio increases, as a result atoms close to the surface are much more reactive than inner ones. "Nanoscience" studies these novel properties and nanomedicine exploits the acquired knowledge to improve existing materials, techniques and products, or to create new ones basing on the novel features (e.g. nanosensors for diagnostics)