JEDI Billion Molecules against Covid19 Grand Challenge
Improve (in silico or others) methods to identify compounds with blocking interactions relevant to any SARS-CoV-2 target, by optimizing/accelerating the use of HPC (High Performance Computing), Artificial Intelligence, and provide experimental validation.
The GrandChallenge will proceed in three stages, where stage 1 and 2 are sequential and stage 3 is independent. Teams can participate in only one or in multiple stages. The aim is to get high-quality lead compounds for multiple SARS-CoV-2 targets by cross-checking multiple simulation approaches. The top-scoring compounds will be analyzed experimentally using direct affinity assays, as well as viral assays on live SARS-CoV-2. A special prize will be awarded for reduction of the yield of infectious virus by > 2-log in cell culture using novel cocktails of already FDA-approved drugs/compounds at sub-micromolar concentrations, and proven effectiveness in an animal model at physiologically relevant doses. All findings will be quickly and publicly shared with the world to battle Covid-19. This challenge is open to any team in the world, requiring breakthrough approaches in computational method and rapid experimental screening. Collaboration of teams in computation, drug development, virology, and clinical models will be necessary.
The uniqueness of this JEDI GrandChallenge is to push for (i) modelling a number of active molecules at a scale never seen before (ii) the determination of a highly accurate list of active compounds cross-correlated by the teams all over the world, (iii) ultra fast-track in-vitro identification of molecules with 2-log reduction in viral activity and (iv) identifying the best drug-cocktail out of existing FDA-approved molecules.
STAGE 1: Deadline for submission is Saturday June 6 at noon CET.