UNIV TS - DSV - Laboratorio di Farmacogenomica

SmartHealth Technological development Trajectories:

Biomedical Technologies, in Vivo and in Vitro Diagnostics

Areas of interest:

Biomedical Technologies, in Vivo and in Vitro Diagnostics, In Vitro Diagnostics, biosensoristics, human clinical diagnosis, omics technologies

The group's research program focuses on basic and translational aspects of the pharmacology of immunomodulatory and antineoplastic agents. Research is focused on the identification and study of molecular and cellular characteristics useful for personalization of these therapies in pediatric patients. Through a combination of pharmacokinetic, pharmacodynamic and pharmacogenomic approaches, molecular and cellular characteristics and their association with patients' response to therapy are evaluated. In particular, investigations consider the personalization of therapy of pediatric inflammatory bowel disease, acute lymphoblastic leukemia, nephrotic syndrome and juvenile idiopathic arthritis.

Keywords:

farmacogenomica personalizzazione delle terapie malattie croniche e oncologiche pediatriche

Progetti del Gruppo di Ricerca

Thalidomide, a novel immunological treatment to modify the natural history of paediatric Crohn's disease: a new proposal from a well- established paediatric research network. NET-2013-02355002

Tipologia Call:

Ministero della Salute

Durata del progetto:

Tre anni

Partneriato:

IRCCS Burlo Garofolo Università di Brescia CRO Aviano

Terapia di precisione per le leucemie linfoblastiche acute pediatriche BCR-ABL-like: sviluppo di un sistema in vitro per la diagnosi ed il monitoraggio clinico

Tipologia Call:

Roche per la Ricerca 2016

Durata del progetto:

1 anno

Cellule staminali pluripotenti indotte derivate dai pazienti per la personalizzazione della terapia: il paradigma della pancreatite da tiopurine nella malattia di Crohn

Tipologia Call:

Fondazione Stiftung

Durata del progetto:

2 anni